EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSESSMENT OF THE PATTERN OF ANTIBIOTIC USE IN THE NEONATAL INTENSIVE CARE UNIT (NICU) AT A TERTIARY HOSPITAL IN THE UAE

*Nosaibah Ahmed Al Antali, Ammar Ali Saleh Jaber, Juliana F. Roos, Ammar Abdulrahman Jairoun

ABSTRACT

Background: The use of antibiotics in NICU is considered to be essential either as a Prophylactic or empirical treatment for a number of diseases. Sepsis is considered as one of the major risk diseases and requires a variety of antibiotics. The proper selection of antibiotics is necessary to ensure a successful treatment outcome. Objective: To investigate the proper use of antibiotics. The type of infection, microbiological culture results, empirical and duration of antibiotic, antibiotic-resistant and risk factors associated with sepsis infection in NICU. Methods: This is a retrospective cross-sectional, non-probability study of all newborn babies admitted at NICU at a Tertiary Hospital in the UAE from 1 January 2018 to 31 December 2018. Results: A total of 256 neonates referred to the neonatal intensive care unit. 19 neonates (7.4%) were diagnosed with late-onset Sepsis (LOS), and none of them was diagnosed with early-onset Sepsis (EOS). About 9 neonates (3.5%) were diagnosed with other infections. All-cause infections in the NICU caused by 85.2% of gram-negative bacteria and 29.6% of gram-positive bacteria. There was a high bacterial prevalence of S.Haemolyticus and K.Pneumoniae by (18.5%) in the NICU. Of probable sepsis cases, 170 cases (91.4%) were prescribed Penicillin+Gentamicin.145 cases (78%) were prescribed an empirical antibiotic for ≤ 72 hours. There was a high prevalence of bacterial resistance of K. Pneumoniae and S.Haemolyticus by (18.5%) in the NICU. The central venous line in neonate major risk factor for sepsis as odds ratio 8.88% following by length of stay in NICU 1.03%, Gestational Age 0.82%, and Birthweight 0.23%. Conclusions: Sepsis represents the major reason for neonate morbidity and mortality. Wise choice of antimicrobial agents and optimal duration of treatment in neonatal with the suspected or culture-proven sepsis is critical in order to limit the use of unnecessary wide spectrum antibiotic treatment and to supply local solutions to the worldwide race against antimicrobial resistance.

Keywords: Neonatal Intensive Care Unit, Empirical Antibiotic, Neonatal sepsis, Bacterial resistance.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )