EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A REVIEW ON CONCEPTUAL OVERVIEW ON DEVELOPMENT AND CHARACTERIZATION OF SUPERPOROUS HYDROGELS A PROMISING TOOL FOR GRDDS

*Nitla Sirisha, D. Vinay Kumar, K. Srinivas Reddy and K. Lowkya

ABSTRACT

In the pharmaceutical field one of the convenient approach in oral drug delivery system to attain desired therapeutic action is done by prolonged release and desired drug delivery in GIT as most of the drugs posses short gastric retention time which eliminates the drug quickly from the stomach this will not produce desired therapeutic action, in order to overcome this, Gastroretentive dosage forms are developed which prevents the gastric emptying of the drug immediately after its administration. So as to overcome this Superporous hydrogels are developed. Superporous hydrogels are generally developed as novel drug delivery systems for those drugs whose absorption window is in stomach and upper part of GIT These systems should immediately swell in stomach and maintain their integrity in the harsh stomach environment. The water absorption by SPHs was done by capillary action not diffusion. Second generation SPH composites and third generation SPH hybrids were developed to achieve good mechanical strength as SPHs are having poor mechanical strength. The synthetic features and properties were being developed from years in order to maintain its integrity in Gastrointestinal tract(GIT). This review discusses the formulation, advantages, disadvantages, methods of synthesis, various generations, drug loading techniques, drying of SPHs and characterization of SPHs.

Keywords: Superporous hydrogel, Gastric retention, Absorption window.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )