PRACTICAL APPROACHES TO THE DIAGNOSIS OF SERUM IL-28 LEVELS IN VIRAL HEPATITIS B IN PREGNANT WOMEN

Zufarova Sh. A., Mirzaabdullahozhieva O. U., *Ismailova A. A., Yuldasheva O. S.

ABSTRACT

According to the results carried out since the discovery of interferons, no one doubts that IFN-λ are polyfunctional. The role of IFN-λ as an interferon that suppresses viral infections on the surfaces of the anatomical barriers of the respiratory tract, gastrointestinal tract, blood-brain barrier and liver has been studied quite extensively and in detail. More recently, studies have appeared on the immunomodulatory role of IFN-λ and its direct and indirect effects on the function of immune cells in various inflammatory conditions, thereby explaining the higher safety profile compared to the undesirable pro-inflammatory effects of IFN-α. Interesting data in the field of infectious diseases, as well as the availability of ready-made pegylated forms of IFN-λ, which have already passed clinical studies and showed a higher safety profile in them than pegylated IFN-α, open scientific and clinical horizons for the study and application of IFN-λ. The studies have shown that the values of IFN-gamma and IL-28, which have pronounced antiviral properties, are significantly suppressed during chronic infection with viral hepatitis B. Research in this area will be continued in order to understand the etiopathogenesis, the characteristics of the course of the infectious process and predict the course of the disease.

Keywords: interferons, immunity, antiviral action, interferon system, antiviral protection of immunity, viral hepatitis B.