ANTIDIARRHEAL EFFECT OF AQUEOUS AND HYDROETHANOLIC EXTRACTS OF ROOTS OF COGNIAUXIA PODOLAENA BAILL (CUCURBITACEAE)

Kiéssé D.S., R. D. G. Elion Itou*, A. W. Etou Ossibi, S. H. Mayela Nkouka, C.J. Morabandza, F. G. Nsondé Ntandou and A. A. Abena

ABSTRACT

This work aimed to evaluate the antidiarrheic effect of the aqueous extracts (300 and 600 mg/kg) and hydroethanolic (300 and 600 mg/kg) of roots of C. podolaena (Cucurbitaceae). This effect was evaluated on frequency and quantity of the faces excreted by using castor oil method. Intestinal transit was evaluated in atropine and of acetylcholin presence by using the charcoal method. In addition, the effect of the two extracts (300 and 600 mg/kg) was evaluated on the intestinal fluid accumulation (enteropooling) and also on Na+ and K+ secretion. The results obtained show that these extracts significantly reduce (p < 0,001) the frequency and quantity of the faces excreted and also increase the onset of diarrheic faces compared to the control group.Moreover, these extracts at dose used significantly reduce (P < 0,001) the intestinal transit, the intestinal fluid accumulation and increase the ratio Na+/K+ compared to the control group. The antidiarrheic effect of the two extracts of C.podolaena could pass by the inhibition of the cholinergic receptors.

Keywords: Cogniauxia podolaena, castor oil, acetylcholine, intestinal transit time, atropine.