EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIDIARRHEAL EFFECT OF AQUEOUS AND HYDROETHANOLIC EXTRACTS OF ROOTS OF COGNIAUXIA PODOLAENA BAILL (CUCURBITACEAE)

Kiéssé D.S., R. D. G. Elion Itou*, A. W. Etou Ossibi, S. H. Mayela Nkouka, C.J. Morabandza, F. G. Nsondé Ntandou and A. A. Abena

ABSTRACT

This work aimed to evaluate the antidiarrheic effect of the aqueous extracts (300 and 600 mg/kg) and hydroethanolic (300 and 600 mg/kg) of roots of C. podolaena (Cucurbitaceae). This effect was evaluated on frequency and quantity of the faces excreted by using castor oil method. Intestinal transit was evaluated in atropine and of acetylcholin presence by using the charcoal method. In addition, the effect of the two extracts (300 and 600 mg/kg) was evaluated on the intestinal fluid accumulation (enteropooling) and also on Na+ and K+ secretion. The results obtained show that these extracts significantly reduce (p < 0,001) the frequency and quantity of the faces excreted and also increase the onset of diarrheic faces compared to the control group.Moreover, these extracts at dose used significantly reduce (P < 0,001) the intestinal transit, the intestinal fluid accumulation and increase the ratio Na+/K+ compared to the control group. The antidiarrheic effect of the two extracts of C.podolaena could pass by the inhibition of the cholinergic receptors.

Keywords: Cogniauxia podolaena, castor oil, acetylcholine, intestinal transit time, atropine.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )