THE TREATMENT OUTCOME OF BREAST CANCER PATIENT

Dr. Abdullah Al Mueed Khan*, Dr. Jobaida Naznin, Dr. Shantanu Das, Prof. Dr. Osul Ahmed Chowdhury

ABSTRACT

Objective: In this study our main goal is to evaluate the treatment outcome of breast cancer patient. Method: This quasi-experimental study was carried out at Dept. of Microbiology, Department of radiotherapy & Department of Surgery, Sylhet MAG Osmani Medical College Hospital from January, 01, 2011 to December, 31, 2011. Samples from the 30 cases were collected, first from Department of surgery (before operative procedure) and then, from Department of radiotherapy (after surgery and 3 cycles of adjuvant chemotherapy) from the same patient. Results: During the study, invasive ductal carcinoma in 28 (93.3%) cases and invasive lobular carcinoma in 2 (6.7%) cases. Lymph node was positive in 18 (60.0%) cases and negative in 12 (40.0%) cases. CD4/CD8 ratio before chemotherapy was 1.7 (SD ± 0.4) and CD4/CD8 ratio after chemotherapy was 1.3 (SD ± 0.5). CD4/CD8 ratio was significantly reduced after chemotherapy than before chemotherapy (Z=3.500; p<0.001). Conclusion: from our study we conclude that, the breast cancer patients demonstrated increased levels of CD4 and CD8+T cells and CD4/CD8 ratio before commencement of any treatment, but the levels were markedly reduced following chemotherapy.

Keywords: breast cancer, CD4/CD8 ratio, chemotherapy.