EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTISECRETORY ACTIVITY OF THE STEM BARK AQUEOUS EXTRACT OF KHAYA GRANDIFOLIOLA (MELIACEAE) IN RATS OCCURS THROUGH ANTICHOLINERGIC AND ANTIHISTAMINIC PATHWAYS

Désirée Sandrine Mbida Essama*, Gustave Lebeau Ndji Otto, Christophe Mezui and Paul Vernyuy Tan

ABSTRACT

Aim: The current study investigated the possible mechanism of antisecretory action of Khaya grandifoliola in rats. Methods: Carbachol and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used. The aqueous extract (250-500 mg/kg) was administered by oral or duodenal route and gastric mucosal ulceration, mucus production, pH, gastric volume, and acidity were measured. Results: Histamine and carbachol raised gastric acidity to 68.89 and 60.00 mEq/L respectively in the control rats. The extract of K. grandifoliola (250 and 500 mg/kg), given by oral route significantly (p< 0.001) reduced histamine-induced gastric acidity to 41.80 and 40.60 mEq/L, and carbachol-induced gastric acidity to 24.42 and 16.40 mEq/L, with 100 percent inhibition of gastric ulceration by the 500 mg/kg dose in the carbachol model. Intraduodenally-administered extract (250-500 mg/kg) significantly (p < 0.001) reduced histamine-induced gastric acidity to 48.73 and 33.84 mEq/L, and carbachol-induced gastric acidity to 26.72 and 26.22 mEq/L. The extract (250-500 mg/kg) significantly reduced (p < 0.001) the volume of gastric secretion and significantly increased mucus production in carbachol-induced hypersecretion only. The ulcer inhibition potential in histamine-induced gastric lesion, at the two doses of the extract of K. grandifoliola, was low (20.79 % and 48.97 %) by oral route, but increased by intraduodenal route (53.92 % and 83.03 %). In carbachol-induced gastric lesion, 250 mg/kg of extract increased ulcer inhibition potential from 29.93 % by oral route to 67.49 % by duodenal route Conclusion: The aqueous extract of K. grandifoliola has both antisecretory and cytoprotective effects. This antisecretory effect may involve a mechanism common to both cholinergic and histaminic pathways with greater effects elicited through the cholinergic pathway.

Keywords: Khaya grandifoliola, gastric ulcer, gastric hypersecretion, antisecretory activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )