DIAGNOSTICS OF THE ACTIVITY OF THE ACCESSORY GLANDS OF THE MALE GENITAL SYSTEM IN INFERTILITY

Yarmukhamedov A. S., Faizullaeva N. Ya. and Musakhodzhaeva D. A.*

ABSTRACT

Background: In the structure of infertile marriage, the tendency towards an increase in the male factor and a deterioration in sperm quality dictates the need for a close study of the existing problem. Objective: We examined 72 patients with impaired fertility, who were aged from 26 to 45 years with diagnoses of oligo-, astheno-, teratozoospermia. Methods: Diagnosis verification was carried out on the basis of clinical, instrumental and laboratory research methods. A biochemical analysis of semen was carried out - the level of citric acid, fructose and zinc was studied to assess the functional capabilities of the prostate gland. Result: A significant decrease in the level of citric acid, fructose and zinc in the semen was revealed, as well as a decrease in the level of inhibin B in the blood serum. Conclusion: Summarizing the data presented, we can assume a probable mechanism for the development of shifts associated with impaired fertility, in which there is a decrease in the level of fructose, citric acid and zinc. At the same time, a decrease in the level of inhibin B in the blood serum is observed. All these changes lead to the activation of phospholipase A2, the production of which is indirectly related to the content of zinc ions; this process is due to the activation of free radical processes in the organs of spermatogenesis and ejaculate. Careful monitoring of spermatozoa, the study of their changes at the structural level, as well as the study of biochemical parameters that can discriminate pathological changes are the priority tasks of laboratory diagnostics.

Keywords: semen, fructose, citric acid, zinc, serum inhibin B, sperm motility.