EFFECT OF DIPEPTIDYL PEPTIDASE 4 INHIBITOR DRUGS IN COMBINATION WITH OTHER MEDICINES IN TYPE 2 DIABETES MELLITUS (T2DM)

Suresh Chandra* and Komal Manwani

ABSTRACT

Dipeptidyl peptidase IV is a focal controller of insulin-animating hormones, glucagon-like peptides, and insulinotropic glucose-subordinate polypeptides. So it's a decent objective for type 2 DM. care, plasma decrease DPP IV protein adds to expanded inherent glucagon, for example, peptide-1, GIP action which at last outcomes in the potentiation of pancreatic islet insulin discharge and ensuing bringing down of blood glucose levels, HbA[1c], glucose emission, the advancement of liver glucose. One of the key objectives of diabetes care is to arrive at restorative methodologies for hemoglobin HbA[1c] and maintain a strategic distance from the inception or decline of a microvascular condition, investigating effectively the DPP IV inhibitor, for example, Sitagliptin and Vildagliptin. A few other novel DPP IV inhibitors are in the pipeline Unless some contraindications for metformin treatment is endorsed and if HbA[1c] targets are not reached after 3 months.several specialist class of drugs could be added in treatment for example, sulfonylurea, Thiazolidinediones, DPP IV inhibitor. Regardless of a wide scope of remedial choices, the accomplishment of HbA[1c] focuses on individuals with diabetes stays testing, with simply over half (52%) of diabetes patients accomplishing a typical HbA[1c] focus of < 7.0%. The present review reveals that the effect of DPP IV inhibitors, combined with other drugs and therapeutic advantages over GLP-1 based approach.

Keywords: Diabetes2 Dipeptidyl Peptidase-4, Glucose-dependent, Polypeptide, Insulinotrophic, Glucagon-like Peptide-1, type 2 Diabetes Mallitus.