EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A CLINICAL NOTEWORTHY BRIEF REVIEW ON PRION DISEASE

Kirti Rani* and Pragya

ABSTRACT

Prion disease is a rare inherited autosomal neurodegenerative disorders whose exact reported prevalence is still unknown. Prions are proteinaceous infectious agents without any nucleic acid. These agents are also termed ‗Transmissible Spongiform Encephalopathies (TSEs)‘ which also caused ‗Mad cow disease‘ in other animals as termed ‗Brain eater agents‘. But various clinical studies are suggested that this disease affects about one person per million worldwide each year. This disease is deteriorated the neuronal conditions with the time that impair brain function, loss in memory, personality disorder and behavior fluctuation, a decline in intellectual function (dementia) and abnormal gait movements and ataxia. The signs and symptoms of prion disease is typically begun in adulthood and progressively worsen with time, leading to brain death within a few months to several years. In, this disease, one copy of the altered PrP gene in each cell is sufficient to cause this neural disorder. In most of the cases, an affected person inherits the altered gene from one affected parent. So, genetic counseling and effective genetic analysis are played very important role to diagnose Prion disease at right time with their existing lethal symptoms during onset of this disease. This disease must be diagnosed, treated and managed well at right time in recorded cases of Prion diseased patients with effective neuroprotective and suggestive clinical measures along with palliative care. Then, it can be medically managed to control its clinical and genetic burden in affected population of any country worldwide.

Keywords: Prion disease; neurodegenerative disorder; ataxia; PrP gene; Prion diseased patients.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )