EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CLINICAL AND IMMUNOGENETIC CHARACTERISTICS IN MEN WITH IMPACTED FERTILITY

Musakhodjaeva D. A.*, Yarmukhamedov A. S., Faizullaeva N. Ya. and Azizova Z. Sh.

ABSTRACT

Immunogenetic disorders can be the cause of idiopathic male infertility. Mutations in the CFTR gene, involved in spermatogenesis or the formation of the male reproductive system, also in many cases cause impaired male fertility. It should be emphasized that there is no information about the state of the cytokine profile and its relationship with the parameters of immunity in infertility in men, as well as the influence of these disorders on the processes of spermatogenesis. Objective: The study involved 135 men with infertility, who were divided into 2 groups: a group of men without CFTR gene mutations and a group with CFTR gene mutations. Result: In the ejaculate, the level of proinflammatory cytokines - IL-2, IL-6 and TNFα - was determined. It was revealed that in men with the presence of CFTR gene polymorphism, the levels of the studied cytokines in the seminal fluid significantly differ from those in men with infertility who do not have mutations in the CFTR gene.

Keywords: male infertility, genetic research, cystic fibrosis, cytokines.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing