CLINICAL AND IMMUNOGENETIC CHARACTERISTICS IN MEN WITH IMPACTED FERTILITY

Musakhodjaeva D. A.*, Yarmukhamedov A. S., Faizullaeva N. Ya. and Azizova Z. Sh.

ABSTRACT

Immunogenetic disorders can be the cause of idiopathic male infertility. Mutations in the CFTR gene, involved in spermatogenesis or the formation of the male reproductive system, also in many cases cause impaired male fertility. It should be emphasized that there is no information about the state of the cytokine profile and its relationship with the parameters of immunity in infertility in men, as well as the influence of these disorders on the processes of spermatogenesis. Objective: The study involved 135 men with infertility, who were divided into 2 groups: a group of men without CFTR gene mutations and a group with CFTR gene mutations. Result: In the ejaculate, the level of proinflammatory cytokines - IL-2, IL-6 and TNFα - was determined. It was revealed that in men with the presence of CFTR gene polymorphism, the levels of the studied cytokines in the seminal fluid significantly differ from those in men with infertility who do not have mutations in the CFTR gene.

Keywords: male infertility, genetic research, cystic fibrosis, cytokines.