EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STUDY OF ANTIMICROBIAL ACTIVITY OF LANTANA INDICA LINN. AGAINST SOME HUMAN PATHOGENS. AND ITS PHYTOCHEMICALS.

Shubha Gupta, Kumudini Indira Toppo, Deepak Karkun and Anil Kumar*

ABSTRACT

Medicinal plants are the wealthy source of the antimicrobial agent and curative. In the present study we carried out the antimicrobial effect and analysis of phytochemical constituents of different parts of Lantana indica Linn (Verbenaceae). Pathogenically significant bacteria (Salmonella typhi-MTCC-733, Staphylococcus aureus- MTCC-7443, Pseudomonas aeruginosa MTCC-7296, Mycobacterium tuberculosis-MTCC-300) and fungus (Microsporum canis-MTCC-2820, Epidermophyton floccossum-MTCC-613, Trichophyton rubrum –MTCC-296, Aspergillus candidus –MTCC-1989) were selected for the study. The extract of root, stem, leaf and flower of plant were prepared in methanol and aqueous solutions and different doses (25 μl, 50 μl, 100 μl, 200 μl, 300 μl and 400 μl) were selected for study by agar disk diffusion method. We found significantly effective antibacterial property of Lantana indica at concentrations of 25 μl to 400 μl against Pseudomonas aeruginosa and at concentration of 400 μl against Salmonella typhi and Staphylococcus aureus but found completely ineffective against Mycobacterium tuberculosis. The significantly effective antifungal activity was found only at 400 μl concentration against Epidermophyton floccossum and Trichophyton rubrum but found completely ineffective against Microsporum canis and Aspergillus candidus.The secondary metabolites of extract effective against microorganisms was evaluated and recognized as saponins, tannins, cardiac glycosides, alkaloids, flavonoids, steroids and terpenoids. The HPLC profiling was also performed and was identified as Lantadens A, B, C, D which is effective agent against above microorganisms.

Keywords: Antimicrobial activity, Medicinal plants, Aqueous extract, Methanol extract, Human pathogens, HPLC.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )