CYTOTOXIC POTENTIAL OF ENDOSULFAN ON OOCYTES OF FEMALE MICE: AN ELECTRON MICROSCOPIC STUDY
Indiscriminate use of pesticides has increased many folds in the recent times. For the better yield of crops, the farmers are widely utilizing the pesticides. These pesticides have deleterious effect on humans causing health related issues in the population which has also led to hormonal imbalance in females leading to infertility. The present research work on animal is harmful impact of endosulfan on reproductive toxicity in female mice. Endosulfan at the dose of 3.0mg/Kg body weight/day was administered by Gavage method to female mice for1 week, 2 weeks, 3 weeks & 4 weeks. At the end of experimental period, decreases of body weight were observed. The study reveals that after the exposure of endosulfan, there was significant damage at the cellular level in ovarian cells of mice. Thus, it is concluded that endosulfan toxicity effect on cellular level of the ovarian oocytes thereby affecting the process of oogenesis and foetal development leading to infertility in female mice.
Keywords: Electron Microscopy; Endosulfan; Oocytes; Mice.
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