EVALUATION OF ANTIMALARIAL ACTIVITY OF PLUMERIA ACUTIFOLIA BARK

Naresh Kumar* and Surendra Kr. Sharma

ABSTRACT

In vitro antimalarial activityof plant Plumeria acutifolia bark has been evaluated by performed serial dilution methods. The different extracts viz. Pet ether, chloroform, methanol and water extract were used. They were tested by using Plasmodium falciparum parasite. Out of these, the chloroform extract of IC50 of 27.3 ± 1.453μg/ml to 100 μg/ml showed significant results against the parasite in vitro study. The above used extracts were tested against Plasmodium berghei parasite was used to evaluate antimalarial activity using in vivo methods. In this experiment found that chlorofrom extract of Plumeria acutifolia bark was active against used parasite as in the chloroform extract used in in vitro study. The chloroform extract of the dose 400 mg/kg showed significant results against the Plasmodium berghei. Hence this studies authenticates traditional uses of the plant using both methods.

Keywords: Plumeria acutifolia; Plasmodium bergheii; Antimalarial activity; Apocynaceae.