PHARMACEUTICAL SYNTHESIS OF PYRIMIDINE DERIVATIVES PROJECTING NEW PHARMACEUTICAL DRUG DESIGN, ALONG WITH ITS ANTIFUNGAL ACTIVITY INCLUDING TOXICITY STUDIES
S. Singh*, Dr. Shamim Ahmad and Dr. Shamsher Alam
Nitrogen containing heterocyclic compounds have received considerable attention due to their wide range of
pharmacological activity. Pyrimidine and their derivatives are considered to be important for medicinal drugs. As
pyrimidine is a basic nucleus in DNA & RNA, it has been found to be associated with diverse biological activities.
Numerous reports have appeared in the literature that highlights chemistry and uses of pyrimidines, and their
derivatives like Sulfadiazine, Sulfamerazine, and Sulfamethazine. A series of Pyrimidine derivatives were
synthesized to evaluate their antimicrobial activity, their structure were characterized by UV, NMR, IR and Mass
spectrometer. Among the tested Pyrimidine derivatives P-1 shows good activity against Penicillium chrysogenum
and lesser toxicity.
Keywords: Antifungal activity, antibacterial activity, analgesic activity, Pyrimidine.
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