EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

ANTI-DIABETIC ACTIVITY OF AQUEOUS AND METHANOLIC LEAF EXTRACTS OF SCHLEICHERA OLEOSA LOUR.

Sophy Jose* and M. P. Sinha

ABSTRACT

Compounds obtained from plants may be good substitutes of the conventional drugs for the effective treatment of diabetes. Schleichera is genus of plant that belongs to the family Sapindaceae. The present study was undertaken to investigate the antidiabetic details of the methanolic and aqueous leaf extract of Schleichera oleosa. Freshly prepared extracts of the powdered leaves were subjected to phytochemical analyses. The amylase inhibition assay was performed using the chromogenic (Dinitro salicylic acid) DNSA method. The methanolic leaf extract of Schleichera oleosa showed 26.191±0.001 percentage of amylase inhibition at 10 μg concentration, 50.131±0.002 percentage of amylase inhibition at 50 μg of concentration and 68.888±0.002 percentage amylase inhibition against 100 μg concentration and aqueous leaf extract of Schleichera oleosa showed 24.123±0.040%, 33.112±.004 % and 55.471±002 % amylase inhibition against 10 μg, 50 μg and 100 μg extract concentration respectively while Acarbose showed 99.833±0.288, 100.133±0.230, and 100.233±0.404 percentage of amylase inhibition against 10 μg, 50 μg and 100 μg the concentrations respectively. Thus we can assume that Schleichera oleosa is a good anti-diabetic agent and can be used in the treatment of diabetic mellitus.

Keywords: Schleichera oleosa, amylase inhibition, antidiabetic activity, Acarbose.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia