ANTI-DIABETIC ACTIVITY OF AQUEOUS AND METHANOLIC LEAF EXTRACTS OF SCHLEICHERA OLEOSA LOUR.
Sophy Jose* and M. P. Sinha
Compounds obtained from plants may be good substitutes of the conventional drugs for the effective treatment of diabetes. Schleichera is genus of plant that belongs to the family Sapindaceae. The present study was undertaken to investigate the antidiabetic details of the methanolic and aqueous leaf extract of Schleichera oleosa. Freshly prepared extracts of the powdered leaves were subjected to phytochemical analyses. The amylase inhibition assay was performed using the chromogenic (Dinitro salicylic acid) DNSA method. The methanolic leaf extract of Schleichera oleosa showed 26.191±0.001 percentage of amylase inhibition at 10 μg concentration, 50.131±0.002 percentage of amylase inhibition at 50 μg of concentration and 68.888±0.002 percentage amylase inhibition against 100 μg concentration and aqueous leaf extract of Schleichera oleosa showed 24.123±0.040%, 33.112±.004 % and 55.471±002 % amylase inhibition against 10 μg, 50 μg and 100 μg extract concentration respectively while Acarbose showed 99.833±0.288, 100.133±0.230, and 100.233±0.404 percentage of amylase inhibition against 10 μg, 50 μg and 100 μg the concentrations respectively. Thus we can assume that Schleichera oleosa is a good anti-diabetic agent and can be used in the treatment of diabetic mellitus.
Keywords: Schleichera oleosa, amylase inhibition, antidiabetic activity, Acarbose.
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