EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION & EVALUATION OF ORAL DISPERSIBLE TABLETS OF CHLORPHENIRAMINE

Bhoye Nitin Keshav*, Shevkar Sagar Dilip, Raghunath Pawar and Prajakta Bhoj

ABSTRACT

Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly patient compliance. The most popular solid dosage forms are the Fast disintegrating tablets and Chlorpheniramine was chosen a choice drug candidate. Since it is drug prescribed especially in elderly patients as antihypertensive and also it is given in the conditions of heart failure an Chlorpheniramine heart attack. The drug is bitter taste in nature and produces noncompliance to patient’s especially geriatric patients. It concluded that INDION 204 resin were useful for masking the taste as well as enhancing the solubility of the drug. Super disintegrants were helpful in formulation of the Oral Dispersible tablets. Crosscarmellose sodium was used as superdisintegrants in formulations. The oral disintegrating tablets of Chlorpheniramine with sufficient mechanical strength, acceptable taste and smaller disintegration time were achieved employ-ing suitable superdisintegrants and other excipients at optimum concentration. Stability studies revealed that there was no significant change in drug content and dissolution profile of oral disintegrating tablets. FTIR studies revealed that there was no shift in peaks, indicating there is no interaction between Chlorpheniramine and other ingredients used. Among three superdisintegrants used, Crosspovidone showed better performance in disintegration time when compared to sodium starch glycolate and Crosscarmellose sodium. So the formulation of F4 was found to be best among all other formulations, because it has exhibited faster wetting time, good taste and faster disintegration time when compared to all other formulations.

Keywords: Chlorpheniramine, Oral Dispersible tablets, superdisintegrants & Crosscarmellose sodium.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing