FORMULATION & EVALUATION OF ORAL DISPERSIBLE TABLETS OF CHLORPHENIRAMINE

Bhoye Nitin Keshav*, Shevkar Sagar Dilip, Raghunath Pawar and Prajakta Bhoj

ABSTRACT

Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly patient compliance. The most popular solid dosage forms are the Fast disintegrating tablets and Chlorpheniramine was chosen a choice drug candidate. Since it is drug prescribed especially in elderly patients as antihypertensive and also it is given in the conditions of heart failure an Chlorpheniramine heart attack. The drug is bitter taste in nature and produces noncompliance to patient’s especially geriatric patients. It concluded that INDION 204 resin were useful for masking the taste as well as enhancing the solubility of the drug. Super disintegrants were helpful in formulation of the Oral Dispersible tablets. Crosscarmellose sodium was used as superdisintegrants in formulations. The oral disintegrating tablets of Chlorpheniramine with sufficient mechanical strength, acceptable taste and smaller disintegration time were achieved employ-ing suitable superdisintegrants and other excipients at optimum concentration. Stability studies revealed that there was no significant change in drug content and dissolution profile of oral disintegrating tablets. FTIR studies revealed that there was no shift in peaks, indicating there is no interaction between Chlorpheniramine and other ingredients used. Among three superdisintegrants used, Crosspovidone showed better performance in disintegration time when compared to sodium starch glycolate and Crosscarmellose sodium. So the formulation of F4 was found to be best among all other formulations, because it has exhibited faster wetting time, good taste and faster disintegration time when compared to all other formulations.

Keywords: Chlorpheniramine, Oral Dispersible tablets, superdisintegrants & Crosscarmellose sodium.