EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CHEMICAL CONSTITUENTS FROM THE AERIAL PARTS OF ARTEMISIA MARITIMA L.

Irshad Ahmad Lone, Mohammad Ali*, M. Sarwar Alam, Showkat Rasool Mir and Shahnaz Sultana

ABSTRACT

Artemisia maritima L. (family Asteraceae) is a stout, slender, much branched shrub. It is used to treat ague, inflammation, intermittent fever, griping, jaundice, ophthalmia, stomach ache, toothache and scorpion sting. The plant exhibits several pharmaceutical properties. The present study was designed to isolate and characterize chemical constituents from the aerial parts of A. maritima. Phytochemical investigations of a defatted ethanolic extract of aerial parts resulted in the isolation of a naphthalene diol identified as 8-ethoxynaphthalene-1,2-diol (1), a phenyl alkene benzyl characterized as 19,27-dimethyl tetratriacont –(Z)-7-ene (2), a phenolic derivative, viz., (Z)- 4-(hexa-1′, 3′-dienyl) pyrogallol (3), a sesamol piperonylic acid derivative viz., 3,4-methylenedioxy phenol 5, 2′-methylene 3′,4′-methylenedioxy benzoic acid (4) and a biflavanone diglycoside recognized as 7-methoxy-3′,4′-dihydroxyflavanonyl-5-oxy-(5→4′′′)-5′′,3′′′-dihydroxy-7′′-methoxyflavanone-4′-α-D-lucopyranosyl-(6a→1b)-α-D-rhamnopyranoside (5). All these chemical constituents are reported for the first time from this plant. GC-MS analysis of a petroleum ether fraction of the alcoholic extract of the aerial parts showed the presence of three aliphatic diols, eight aliphatic triols and one monohydroxy alcohol. The major constituents detected were n-hexatriacont-18-en-17-ol (12.7 %), n-cosan-1,4,11-triol (12.4 %), n-cosan-1,6,18-triol (10.8%) and n-cosan-1,10,17-triol (10.7 %). Two alcoholic constituents detected in small amounts were n-henecosan-1,7-diol (2.7 %) and n-cosan-1,5,12-triol (2.6 %). Except n-hexatriacont-18-en-17-ol, all the alcoholic constituents were saturated in nature.

Keywords: Artemisia maritima, aerial parts, ethanolic extract, phytoconstituents, isolation, characterization.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing