A REVIEW: ANKYLOSING SPONDYLITIS

Dr. Prashant Dattatray Shinde*, Priyanka Kundlik Sabale, Manisha Sunil Zaware, Amarsingh Suresh Devadhe, Pravin Ramdas Adsul, Prachi Amarsingh Devadhe

ABSTRACT

The disease in which inflammation in spinal cord and large joint cause is called as ankylosing spondylitis. These disease immune-mediated diseases that can cause the inflammation to the axial skeleton as well as some joint of the body like peripheral joints. Two centuries ago these Ankylosing spondylitis (AS) disease was firstly described in India. The people who are around 50 year old, in those people this Ankylosing disease mainly observed in the males people are greatly affected by this disease as compare to female. It is a long standing inflammatory autoimmune disease. Mostly severe, chronic pain, and in more advanced cases, spine fusion can cause. The cells of Immune system and natural cytokines have been suggested to be critical in the pathogenesis of AS, especially in the human leukocyte antigen and the interleukin axis. The pathogenesis of this ankylosing spondylitis disease is not found clearly. In all over India around half percent of patients which is affected by these disease they shows the bowel inflammation in bowel and hence it is confirmed that the real origin of the disease could be in these stomach of our body. Finally in this review, we conclude that the treatment of AS includes Non-steroidal anti-inflammatory drugs which importantly reduced inflammatory indication as well as are present initial drug treatment for these disease.

Keywords: HLA-B27, ankylosing spondylitis, Functional limitation, sacro-iliac joint, Inflammation & Spinal cord.