A REVIEW ON MICROENCAPSULATED AND NANOENCAPSULATED NASAL DRUG DELIVERY SYSTEM

Harshada A. Kadam* and Nikhil A. Gade

ABSTRACT

The utilization of a nasal route for drug delivery has been used in recent years within the pharmaceutical field , because it has been reveal that the many drugs have better better by nasal route than oral route. Local and systemic drug delivery are also achieved by this route of administration. But the nasal route of delivery isn’t applicable to all or any drugs. The nasal delivery route has the advantages, including convenience and easy use, they have rapid onset of action, the avoidance of immediate hepatic metabolism, gut wall metabolism or destruction in the gastrointestinal tract, also the possibilities of to reduce systemic exposure, higher the bioavailability, and have a rapid brain access through the nerves. Drug delivery systems including liposomes, cyclodextrins, micro- and nanoparticles are being investigated to increase the bioavailability of medicines delivered intranasally. This criticism discusses recent progress and specific development issues regarding to colloidal drug delivery systems used in the nasal drug delivery.

Keywords: Nasal delivery. Nasal bioavailability, Liposomes, Microsphere, Nanoparticles.