EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EPIDERMAL GROWTH FACTOR IMPROVES THE ULTRASTRUCTURAL PICTURE OF SUBMANDIBULAR SALIVARY GLANDS OF ALBINO RATS TREATED WITH A SINGLE BOTULINUM TOXIN INJECTION- A QUALITATIVE STUDY.

Mohamed Shamel*, Mahmoud M. Al-ankily, Mahmoud M. Bakr and Moataz ElKholy

ABSTRACT

Background: Botulinum toxin (BTX) is well known for its cosmetic as well as medical and dental uses. One of BTX main uses is the control of hypersalivation by intraglandular injection. However, some unwanted changes in the salivary gland elements have been detected. The aim of the current study was to explore if the effect of Epidermal growth factor was enough to heal the damage caused by botulinum toxin type A in submandibular salivary glands of rats. Methods: 21 adult albino rats were divided into three groups: Control Group, BTX Group B where rats received a single Botox® (BTX) injection subcutaneously, and EGF Group in which rats received intraperitoneal EGF daily for two months after the single BTX injection. After the experimental procedures, submandibular salivary glands were cut out and examined using transmission electron microscopy. Results: The BTX group showed severe signs of atrophy and damage which affected all glandular components. This was revealed in the form of degeneration, intracytoplasmic vacuolations and decrease in the number of desmosomal junctions. The EGF group showed marked improvement in acinar and ductal elements of the submandibular salivary glands. Conclusions: EGF restored the structural integrity of submandibular salivary glands in rats treated with a single BTX injection. Further quantitative studies were deemed necessary to evaluate the various degrees of damage by BTX and repair by EGF.

Keywords: Submandibular salivary gland – Epidermal growth factor – Botulinum toxin – Clostridium – Ultrastructure – Electron microscope.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing