WHAT IS THE PROFILE OF PATIENTS WITH TYPE 2 DIABETES AND NON-ALCOHOLIC FATTY LIVER DISEASE?

Sadikova Dildora Shukhratillaevna* and Khaydarova Feruza Alimovna

ABSTRACT

Prevalence of non-alcoholic fatty liver disease (NAFLD) increases dramatically. Type 2 diabetes (DM2) increases the risk of developing NAFLD, and the presence of NAFLD increases the risk of developing type 2 diabetes. The aim of our work was to study the profile of patients with NAFLD and DM2. We analyzed the profile of 582 patients treated at the Department of Diabetology of the RSSPMCE in 2019. 27% patients had non-alcoholic steatosis (NAS), 8% non-alcoholic steatohepatitis (NASH) based on fibroscanning after detection of steatohepatosis on liver ultrasound. Patients with NAS and NASH did not differ in gender, age, and glycemic control, from patients without NAFLD. 40% patients without NAFLD, 40% with NAS and 54% of patients with NASH had arterial hypertension, isolated diastolic hypertension (IDAH) occurred in 10.4% of patients with NASH, in 7% of patients with NAS, and in 5% of patients without NAFLD. Among patients without steatohepatosis diagnosed by ultrasound of the liver, there was a high proportion of people with an estimated NAFLD fibrosis score corresponding to stages 3-4 of fibrosis, which indicates the need for an active search for NAFLD in people with type 2 diabetes before the appearance of ultrasound signs of steatohepatosis in order to timely initiation of adequate treatment. We are continuing research to determine the optimal algorithm for the active search for NAFLD in people with type 2 diabetes.

Keywords: non-alcoholic fatty liver disease, type 2 diabetes, steatohepatosis, steatohepatitis.