EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

ANTIBACTERIAL AND ANTIFUNGAL STUDIES OF CO(II), NI(II) AND ZN(II) COMPLEXES OF 6-PYRIDYL-5,6-DIHYDROBENZO[4,5]-IMIDAO[1,2-C] QUINAZOLINE (N-N)

Chaithra K.*, H. G. Bheemanna and V. Gayathri

ABSTRACT

Cobalt(II), Nickel(II), and Zinc(II) salts react with a bidentate N-heterocycle, 6-pyridyl-5,6-dihydrobenzo[4,5]- imidao[1,2-C] quinazoline (N-N) to yield complexes of the composition MX2(N-N). nH2O (n = 0, M = Co, X = I or ClO4; n =1, X = Cl or Br; n = 0, M = Ni, X = Br; n = 0, X = Cl or ClO4; n = 0, M = Zn, X = Cl) and [{Zn (OClO3)(N-N)1.5}ClO4]2. The complexes are insoluble in common organic solvents but are soluble in dimethylformamide in which they behave as non-electrolytes excepting the chloro, bromo complexes of cobalt and the complex [{Zn(OClO3)(N-N)1.5}ClO4]2 which behave as uni-univalent electrolytes. The antimicrobial activity has been carried out using gram positive and gram-negative bacteria like Staphylococcus Aureus, Pseudomonas species, Bacillus species, E-Coli, Klebsiella at different concentration by Agar diffusion method and some fungus species like Aspergillus, Penicillium, Candida have been tested. The results are compared with the standard drug Amoxicillin 500 mg. The activity index was recorded using zone of inhibition.

Keywords: Cobalt, nickel, zinc, quinazoline complexes, N-heterocycle, antimicrobial, antifungal, Agar diffusion.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia