EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ACUTE ORAL TOXICITY OF RHUMAVIN CAPSULE (POLY HERBAL FORMULATION) WITH ITS EFFECT AGAINST RHEUMATOID ARTHRITIS

Nilesh Patel, Dr. Janmejay Patel, Achal Patel and Prof. Dr. Upendra U. Zala*

ABSTRACT

Introduction: In Contempt of the availability of advanced medicinal systems, approximately 80% of the world population still depends on herbs and herbal formulations for the treatment of arthritic conditions. Though it is in use for wide variety of clinical applications, toxicological evaluation of herbal ingredients or combinations is still in infancy. Aim: To evaluate acute oral toxicity on Swiss albino mice and efficacy with anti-oxidant properties on arthritic rats of Rhumavin capsule. Method: The protocol of present study was certified by IAEC (SKPCPER/IAEC/2016-02/05) as per the CPCSEA. The acute oral toxicity was assessed according to OECD guideline AOT-425 to know single dose (2000 mg/kg) toxicity of test drug on swiss albino mice. Animals were periodically observed individually for 14 days for any clinical signs of toxicity or mortality after administration of test drug. Bovine serum denaturation assay (In-vitro) was done to investigate effectiveness of Rhumavin capsule on arthritis. FCA induced arthritis animal model (In-vivo) was adopted to check therapeutic effectiveness of Rhumavin capsule against arthritis. FCA was challenged to sub plantar region after treatment in Rats and various parameter were measured i.e. paw volume, arthritic index, hematological and radiological parameters. Different assay analysis (total protein, SOD activity, Catalase activity, Lipid peroxidation) were done to establish its anti-oxidant properties. Results: There were no physical changes, behavioral changes and mortality observed in Swiss albino mice during 14 days. Body weight of all animals did not reveal any significant change as compared to vehicle control group. Rhumavin capsule decreased significantly paw volume, Arthritic index, hematological parameters compared to disease control group. The significant increase in SOD and catalase level was found in test drug treated group. Conclusion: The No-Observed-Adverse-Effect-Level (NOAEL) of Rhumavin capsule is 2000 mg/kg. The results suggest anti- inflammatory, anti-arthritic and antioxidant effect of Rhumavin capsule.

Keywords: Poly herbal formulation (PHF), Rhumavin capsule, NOAEL, Mortality, OECD Guideline, Rheumatoid Arthritis, Anti-oxidant.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing