FABRICATION, CHARACTERIZATION AND OPTIMIZATION OF GASTRO RETENTIVE FLOATING TABLETS OF MOXIFLOXACIN USING NATURAL AND SEMISYNTHETIC POLYMERS
C. Sadak Vali*, Abdullah Khan, M. Pratibha Bharati, Asma Khanam, M. Shaoukhatulla, M. Pradeep Kumar, B. Nageswara Naik and S. Siva Prasad
Gastro retentive drug delivery systems remain in the stomach for a longer period and control release of drug from dosage form. The rationale of present research work is to design, formulate and evaluate gastro retentive formulation for moxifloxacin using various excipients which release the drug in a sustained manner for 12 hrs. Moxifloxacin is a novel synthetic fluoroquinolone, an antibacterial drug. Gastro retentive floating tablets of moxifloxacin were fabricated using variable amounts of hydrophilic and hydrophobic retardants in different combinations for the preparation of tablets. Retardants like HPMC K100M along with effervescent blends were combined to produce tablets by wet granulation procedure. In the present study 9 formulations were designed, prepared and are assessed for various pharmacopoeial properties like weight uniformity, hardness, friability, floating lag time, gastro retentive floating time, assay, swelling time and In-vitro drug release. Drug release reports of preparations were subjected to pharmacokinetic kinetic statistic modeling. Various Parameters were determined. The outcome of evaluation of all formulations reveals that gastro retentive floating lag time increase with an increase in concentration of polymer combination. According to SUPAC guidelines, formulation trail (F-7) containing 60mg of HPMC K100M and 80mg of tragacanth gum was found to be best-optimized formulation. Formulation F-7 drug release was found to adopt first-order kinetics, Non-Fickian diffusion anomalous transport (n=0.75). The optimized formulation (F-7) exhibited adequate extended drug release and endured buoyant on the surface of the medium for greater than 12 hours.
Keywords: Moxifloxacin, Gastro Retentive Drug Delivery System (GRDDS), Floating Tablet, hydroxypropyl methylcellulose K100M, diffusion mechanism.
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