FORMULATION AND EVALUATION OF MEGESTROL ACETATE IMMEDIATE RELEASE TABLETS
Rajalakshmi A. N.*, Padmapriya S. and Devagi K.
The aim of the present study is to have better patient compliance and reduce the developmental cost of Megestrol acetate formulation as an immediate release tablets. Megestrol acetate immediate release tablets were prepared by wet granulation technique using croscarmellose sodium as superdisintegrant. The formulated tablets were evaluated for various pre-compression parameters like bulk density, tap density, compressibility index and angle of repose. The post-compression parameters include weight variation test, hardness, thickness, friability, disintegration test, assay and related substances. The optimized formulation was taken for in-vitro dissolution study and stability studies. Among all the formulations, F6 showed better drug release.
Keywords: Megestrol acetate, immediate release tablets, wet granulation.
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