CHEMICAL CONSTITUENTS FROM THE AERIAL PARTS OF BARLERIA PRIONITIS L.

Imran Khan, Hinna Hamid, Mohammed Ali*, Mohammad Sarwar Alam, and Showkat Rassol Mir

ABSTRACT

Barleria prionitis L. (family Acanthaceae) is an erect, perennial, prickly, much branched shrub, used to treat catarrh, dropsy, dysuria, gastrointestinal disorders, jaundice, hepatic, nervine, paralytic and urinary disorders, rheumatism and sinusitis. This research work was proposed to isolate chemical constituents from the plant aerial parts and to characterize their structures. An ethanol extract of the aerial parts was adsorbed with silica gel for column, dried and chromatographed over a silica gel column packed in n-hexane. Various solvent mixtures of increasing polarity, viz., n-hexane, ethyl acetate and methanol were used to elute the column. The isolated chemical constituents were characterized as oleic acid (1), herniarin (7-methoxycoumarin, 2), 1-hydroxyanthraquinonyl (3→7′)-coumarin (3), 8-dehydroxyemodin-(5→5′)- 8′-dehydroxyemodin (4), n-tetracosane (5), (Z)-n-heptatriacont-8-ene (6), β- sitosterol n-octadec-9ʹ-enoate (β- sitosterol oleate, 7), stigmast-5,22–dien-3β –ol 3-O-α-D-glucopyranoside (8) and [1,1'-biphenyl]- 2,3,4,5,6, 2', 3', 4', 5',6'-decaol (9). Their structures were established on the basis of spectral data analysis and chemical reactions.

Keywords: Barleria prionitis L., aerial parts, extraction, phytoconstituents, isolation, spectral data, characterization.