A STUDY ON LIPID PROFILE IN CHRONIC KIDNEY DISEASE PATIENTS
Dr. V. Viknesh*, Dr. Vigneshwar M., Dr. M. J. Jacob
• Cardiovascular disease(CVD)is a major cause of mortality in patients with mild to moderate chronic kidney disease(CKD) and end-stage renal disease(ESRD).[1,2]
• Primary care physicians(PCP) often manage patients with CKD in the early stages of the disease and have a pivotal role in affecting long term outcomes in CKD patients related to cardiovascular and all-cause mortality.
• In a retrospective cohort study only a tiny minority of patients (0.5–1%) with mild to moderate CKD developed ESRD over a 5-year follow up, while as many as 19 and 24% of the patients with mild and moderate renal insufficiency, respectively, died mostly of cardiovascular complications in the same period.
• Hyperlipidemia, one of the important risk factor of atherosclerosis, is an abnormality commonly encountered in patients with chronic kidney disease.
• Other risk factor includes hypertension, diabetes mellitus, smoking, and obesity.
• Indian studies on lipid profile abnormalities in chronic renal failure (CRF) have varied from no abnormalities at all to significant abnormality (Hypertriglyceridemia and reduced HDL) as described in the Western literature. (NKFK/DOQI) guidelines, which plays a vital role in development of atherosclerotic cardio vascular disease.
• There is also associated thyroid dysfunction seen in CKD patients. A few reports have appeared from India, where various parameters of thyroid function were measured in patients with CRF. In order to gain further insight, this study included measuring the Thyroid Stimulating Hormone(TSH) levels.
[Full Text Article]