A PROSPECTIVE OBSERVATIONAL STUDY ON THE EFFICACY OF PANTOPRAZOLE-DOMPERIDONE COMPARED WITH PANTOPRAZOLE-ITOPRIDE COMBINATION IN TYPE 2 DIABETIC GASTROPARESIS – A PILOT STUDY

Malavika Ashok, Bency Bernard, Archana J. R., Surabhi S. V., Silvia Navis*, Prasobh G. R. and Grace N. Raju

ABSTRACT

Background: Diabetic Gastroparesis is outlined as a clinical condition that is characterized by upper GI dyspeptic symptoms (nausea, bloating, vomiting, weight loss, post prandial fullness) in association with delayed gastric emptying leading to poor glycemic management, poor nutrition and dehydration. We intend to assess which of the combination is better when comparing Pantoprazole-Itopride with Pantoprazole-Domperidone. Methods: A prospective observational study with total of 20 diabetic patients who visited the Department of Gastroenterology at a tertiary care hospital and with abdominal symptoms as their chief complaints were enrolled for the study in whom blood glucose tests were performed, which revealed Diabetic Gastroparesis condition. Results: A Total of 20 patients with Diabetic Gastroparesis fulfilling the study criteria were included. Using paired t-test, statistical analysis clearly depicts that Pantoprazole – Itopride with a p value 0.001 is comparatively effective than Pantoprazole – Domperidone with a p value of 0.03. Conclusion: The aim of the study was to promote the symptomatic betterment in Diabetic Gastroparesis patients thereby to improve the quality of life in them. The present study demonstrated that the symptoms presented by the patient was improved after receiving the therapy and was recorded higher in Pantoprazole – Itopride group when compared to Pantoprazole – Domperidone group. However larger number of samples and longer duration of study are required to produce valuable and reliable results.

Keywords: Diabetic Gastroparesis, symptomatic betterment, adherence, gastric emptying, quality of life, efficacy, blood glucose.