EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A PROSPECTIVE OBSERVATIONAL STUDY ON THE EFFICACY OF PANTOPRAZOLE-DOMPERIDONE COMPARED WITH PANTOPRAZOLE-ITOPRIDE COMBINATION IN TYPE 2 DIABETIC GASTROPARESIS – A PILOT STUDY

Malavika Ashok, Bency Bernard, Archana J. R., Surabhi S. V., Silvia Navis*, Prasobh G. R. and Grace N. Raju

ABSTRACT

Background: Diabetic Gastroparesis is outlined as a clinical condition that is characterized by upper GI dyspeptic symptoms (nausea, bloating, vomiting, weight loss, post prandial fullness) in association with delayed gastric emptying leading to poor glycemic management, poor nutrition and dehydration. We intend to assess which of the combination is better when comparing Pantoprazole-Itopride with Pantoprazole-Domperidone. Methods: A prospective observational study with total of 20 diabetic patients who visited the Department of Gastroenterology at a tertiary care hospital and with abdominal symptoms as their chief complaints were enrolled for the study in whom blood glucose tests were performed, which revealed Diabetic Gastroparesis condition. Results: A Total of 20 patients with Diabetic Gastroparesis fulfilling the study criteria were included. Using paired t-test, statistical analysis clearly depicts that Pantoprazole – Itopride with a p value 0.001 is comparatively effective than Pantoprazole – Domperidone with a p value of 0.03. Conclusion: The aim of the study was to promote the symptomatic betterment in Diabetic Gastroparesis patients thereby to improve the quality of life in them. The present study demonstrated that the symptoms presented by the patient was improved after receiving the therapy and was recorded higher in Pantoprazole – Itopride group when compared to Pantoprazole – Domperidone group. However larger number of samples and longer duration of study are required to produce valuable and reliable results.

Keywords: Diabetic Gastroparesis, symptomatic betterment, adherence, gastric emptying, quality of life, efficacy, blood glucose.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing