PROSPECTIVE OBSERVATIONAL STUDY IN A MEDICATION SAFETY EVALUATION OF ANTI-PSYCHOTICS IN SCHIZOPHRENIA
SK. Sameera, T. Sravanya, A. Usha Enkeshwari, K. Swapna Madhuri, T. Mounika, Dr. P. Narayana Swamy* and Dr. Sankara Lakshmikanth
Background: Schizophrenia is a severe form of mental illness, with a variety of positive, negative, cognitive and mood symptoms, anti- psychotic medications can have dramatic impact in patient life leads to many side effects. The purpose of this study was to observe Side Effects (weight gain, Blood Pressure, Sedation and Extra Pyramidal Side Effects) of Anti-Psychotics (Chlorpromazine, Haloperidol Vs Olanzapine, Risperidone). Method: A prospective observational study has been carried out in Jayabharath hospital, Nellore from June – December 2019 for a study period of 6 months i.e., June – December 2019. Number of patient enrolled with antipsychotics were Haloperidol (n=15), Chlorpromazine (n=15), Risperidone (n=35) and Olanzapine (n=25), a total of (n=90) patients. Results: Olanzapine resulted in 4kg and risperidone of 2kg increased weight were seen. Extra pyramidal side effects observed with haloperidol and risperidone were dystonia, tremors and rabbit syndrome. A sedation profile observed with chlorpromazine (80%), olanzapine (36%) and their incidence of sedation was compared, which shows that chlorpromazine caused more sedation than olanzapine in case of schizophrenic patients. Conclusion: Prominent Side effects were observed with haloperidol, and risperidone compared to olanzapine, and chlorpromazine. Weight gain was much observed with olanzapine than risperidone. Sedation was more with chlorpromazine than olanzapine and extra pyramidal side effects were predominantly found with haloperidol, whereas the metabolic side effects predominated the atypical antipsychotics.
Keywords: schizophrenia, anti-psychotics, weight gain, sedation, extra pyramidal side effects.
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