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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



SK. Sameera, T. Sravanya, A. Usha Enkeshwari, K. Swapna Madhuri, T. Mounika, Dr. P. Narayana Swamy* and Dr. Sankara Lakshmikanth


Background: Schizophrenia is a severe form of mental illness, with a variety of positive, negative, cognitive and mood symptoms, anti- psychotic medications can have dramatic impact in patient life leads to many side effects. The purpose of this study was to observe Side Effects (weight gain, Blood Pressure, Sedation and Extra Pyramidal Side Effects) of Anti-Psychotics (Chlorpromazine, Haloperidol Vs Olanzapine, Risperidone). Method: A prospective observational study has been carried out in Jayabharath hospital, Nellore from June – December 2019 for a study period of 6 months i.e., June – December 2019. Number of patient enrolled with antipsychotics were Haloperidol (n=15), Chlorpromazine (n=15), Risperidone (n=35) and Olanzapine (n=25), a total of (n=90) patients. Results: Olanzapine resulted in 4kg and risperidone of 2kg increased weight were seen. Extra pyramidal side effects observed with haloperidol and risperidone were dystonia, tremors and rabbit syndrome. A sedation profile observed with chlorpromazine (80%), olanzapine (36%) and their incidence of sedation was compared, which shows that chlorpromazine caused more sedation than olanzapine in case of schizophrenic patients. Conclusion: Prominent Side effects were observed with haloperidol, and risperidone compared to olanzapine, and chlorpromazine. Weight gain was much observed with olanzapine than risperidone. Sedation was more with chlorpromazine than olanzapine and extra pyramidal side effects were predominantly found with haloperidol, whereas the metabolic side effects predominated the atypical antipsychotics.

Keywords: schizophrenia, anti-psychotics, weight gain, sedation, extra pyramidal side effects.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia