EVALUATION OF PATIENT COMPLIANCE AND DEPRESSIVE SYMPTOMS ASSOCIATED WITH POLYPHARMACY IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Dr. Basavanna P.L.*, Dr. Niranjan M.R., Albin M. Antony, Annpriya Thampy, Jijo Joji and Joann Mary Jose

ABSTRACT

Background: CKD is defined as an irreversible condition with abnormalities of kidney structure or function, present for > 3months, with implication of health. Kidney damage includes a wide range of abnormalities and is observed during clinical assessment. GFR is accepted as the overall index of kidney function. It is very difficult to identify CKD in its early stage. Several issues contribute to high prevalence in India. Diabetes and hypertension account for 40%-60% CKD in India. As per Indian Counsel of Medical Research, prevalence of CKD is increased by 6.3%. Due to lifestyle diseases there is a 30% increase in the CKD in US. Smoking, obesity, older age family history also contributes to the development of CKD. In our study male patients with older age are dominant with CKD. Objectives: The main objectives was to assess the compliance and depressive symptoms among the patients receiving polypharmacy in Chronic Kidney Disease. Materials And Methods: Prospective observational analysis of CKD cases admitted to KR Hospital over a period of 6 months from November 2018 to April 2019 was carried out with a sample size of 168. The data obtained was analyzed by using SPSS version 20. Result: Among 168 patients 111 patients were male patients and 57 patients were females. In the study population 77 patients were low adherent to the treatment and 60 patients were moderately adherent and 31 patients were highly adherent. In 168 patients 56 patients were with minimal depressive symptoms (33.3%), 57 patients were with mild depressive symptoms (33.9) and 36 patients with moderate depressive symptoms (21.4%). Only 4 patients were observed with severe depression (2.4%). In the study furosemide was the drug that caused highest incidence of ADR. Conclusion: Our study reveals that most of the patients are with poor adherence to medication. Depressive symptoms are more prevalent in CKD patient. Most of the patients in our study were shown minimal depressive symptoms and incidence of depression was more observed in female patients. In CKD patients depression is unrecognizable in most of the patients. So it is the duty of the pharmacist to make aware the patients about the indication and side effect of the drugs. And also to provide patient counseling to make the society to more adherent to the medication and to prevent depression.

Keywords: Chronic Kidney Disease (CKD), Patient compliance, Depressive symptoms, polypharmacy, Adverse Drug Reaction.