TO STUDY THE BONE MINERAL DENSITY IN NEWLY DIAGNOSED CHILDREN OF CELIAC DISEASE.

Dr. Sudhir Mehta*

ABSTRACT

Objective: To study the bone mineral density in newly diagnosed children of celiac disease. Material and Method: Osteoporosis is a common finding in adult celiac disease patients; however, there are still few data regarding children and adolescents. In the present study we measured the bone mineral density (BMD) in children and adolescents at diagnosis of celiac dis-ease. Study sample consist of thirty seven newly diagnosed pediatric patients of celiac disease. Detailed medical history, drug history, physical examination, complete blood count, erythrocyte sedimentation rate, calcium profile, liver and renal biochemistry, 25-OH-D, Blood sugar were performed. Other investigations like blood sugar, electrolytes and thyroid function tests were studied. Sera of all patients were tested for presence of IgA tissue transglutaminase (TTG) antibody by ELISA using commercially available kits and confirmed by UGI guided endoscopic biopsy. BMD of all these newly diagnosed patients of celiac disease was done with DXR and compared with age match appropriate control. Results: Lumbar spine and whole-body BMD values at diagnosis of celiac disease were significantly lower than in control subjects (P = 0.013 and P = 0.0001, respectively) after differences in age and anthropomorphic variables were con-trolled for. Conclusion: These results emphasize the need for an early diagnosis and treatment in patients with celiac disease to obtain an adequate peak bone mass appropriate for age.

Keywords: Bone Mineral Density, Celiac Disease, Osteopenia.