NOVEL SOLUBILITY ENHANCEMENT METHOD: CRYSTALLO-CO-AGGLOMERATION (CCA) TECHNIQUE
Vishnu B. Nair*, Tina Raju, Dr. Lal Prasanth M. L., Shibu Prasanth C. R.
Crystallo-co-agglomeration (CCA) is an innovative technique developed with the intention to provide the drugs with good micromeritic and mechanical characteristics. The process of CCA involves crystallization followed by simultaneous agglomeration of the drug with the aid of a good solvent and/or a bridging liquid and a bad solvent. This process enables designing of spherical agglomerates containing low dose drugs which have poor flowability. This article contains a detailed insight on CCA, general strategies used for obtaining agglomerates, processing vessel, stages of growth, kinetics, solvent system, limitation, significance, applications and evaluation parameters.
Keywords: Crystallo co-agglomeration, bad solvent, good solvent, crystallization, agglomeration.
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