EFFECT OF VITAMIN D SUPPLEMENTATION ON THE SIZE OF UTERINE FIBROIDS
Dr. Shiuly Chowdhury*, Dr. Minhazul Islam, Dr. Shuva Shrestha and Dr. Shahjada Selim
Background: Uterine fibroids are benign smooth muscle tumors of the uterus. There is a high prevalence of vitamin D deficiency in patients with uterine fibroids. However, the impact of vitamin D on the reduction of the size of the uterine fibroid is still unknown. Objective: The objective of this study was to determine the effect of vitamin D supplementation on the size of uterine fibroids. Materials and Method: A total of 47 participants diagnosed as uterine fibroids (size less than 5 cm) were included in the study. The size of the fibroid was determined by ultrasonography. Baseline vitamin D investigation was done to assess the level of vitamin D. Then vitamin D was supplemented to the participants for three months and repeat ultrasonography was done at 3 months. Regression of the size of fibroid was also done. Results: The mean age was 37.6±8.2 years. Mean vitamin D was 20.32±8.03. According to fibroid size <3cm (small), 3-3.9 cm (medium) and 3.9-4.9 cm (large) at the initial stage was 36.2% (n=17), 48.9% (n=23) and 14.9% (n=7) participants, respectively. After vitamin D supplementation, it became 61.7% (n=29), 31.9% (n=15) and finally 6.4% (n=3). The mean size of fibroids was 3.26±0.74 and after vitamin D supplementation it had been reduced to 2.85±0.78. Furthermore, we found that, according to vitamin D status of deficiency (<20), insufficiency (20-29.9), and sufficiency (≥30) all mean value of follow up fibroids were significantly reduced. Conclusion: Vitamin D supplementation in women helps regress the size of uterine fibroids and it is more effective in small sizes.
Keywords: Uterine fibroid (UF), vitamin D, 25[OH] D.
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