EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ANTIMICROBIAL SUSCEPTIBILITY OF THE MICROORGANISMS ISOLATED FROM DIABETIC FOOT INFECTION - OBSERVED IN TERTIARY CARE HOSPITAL

Talukder MRH*, Alam MNA, Anwar R., Alam H., Ullah M. E. and Haque A. A.

ABSTRACT

Background: Diabetic foot infections (DFIs) are major public health problems and knowledge of microbes causing infections are helpful to determine proper antibiotic therapy. Aims: The aim was to investigate the antimicrobial susceptibility pattern of microbes in DFIs. Methods: An observational study was conducted for a period of 6 months in the Department of Surgery and Microbiology BIRDEM General Hospital. During this period, 108 patients having DFIs admitted in the general surgery wards were tracked from the hospital data management system. Samples (pus/wound swabs) were examined as Gram‑stained smear and cultured aerobically on blood agar and MacConkey agar media. Antimicrobial susceptibility test was performed by disc diffusion techniques according to Clinical and Laboratory Standards Institute guidelines. Results: Of the 108 specimens of the diabetic foot, culture showed monomicrobial growth in 50% (54/108) and polymicrobial growth in 37 %( 40/108). Prevalence of Gram-negative organisms (80.1%, 109/136) was found to be more than Gram‑positive organisms (18.4%, 25/136). Klebsiella species was the most frequent pathogen (26.4% 36/136). Colistin, nitelmycin, piparcillin and tazobactum were the most active against gram-negative microorganisms while gentamicin and vancomycin were the most active agents against gram-positive microorganisms. Conclusion: Prevalence showed Gram‑negative bacteria was more than Gram-positive bacteria in diabetic foot ulcers. The data may help develop and update local clinical guidelines regarding antibiotic therapy for diabetic foot infections. Lack of detection facilities for anaerobic bacteria is a limitation of this study.

Keywords: Antimicrobial susceptibility, Diabetic foot infection (DFI).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia