WOUND HEALING POTENTIAL OF AZADIRACHTA INDICA(NEEM) LEAVES

Vijaya Paul Samuel, *Laxminarayana Kurady Bairy, Kumar Bhat, Sareesh N. N., Suresh Kumar and Hemant Yadav

ABSTRACT

Azadirachta indica (A.indica) is a frequently used medicinal plant in indigenous medicine. A study was carried out to investigate the wound healing ability of aqueous extract of A.indica. In this study two wound models namely; excision and incision wounds were used. The period of epithelization and wound contraction for excision wound and tensile strength for incision wound were the selected parameters respectively. A.indica increased the tensile strength in case of incision wound; and decreased the epithelization period and enhanced wound contraction in case of excision wound. Further, A.inidca was able to reverse the decreased tensile strength, delayed epithelization period, and wound contraction due to dexamethasone treatment. In, conclusion, the aqueous extract of A.indica has pro-healing effect and was effective in negating the anti-healing effect of dexamethasone.

Keywords: Azadirachta indica, Incision wound, excision wound, dexamethasone.