EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICALS AND ANALGESIC PROPERTIES OF THE METHANOL STEM BARK EXTRACT OF ADANSONIA DIGITATA L. IN MICE

Shehu Yakubu Magaji*, Suleiman Yunusa, Ahmad Ali Darazo, Zainab Gambo Ibrahim and Ibrahim Muhammad

ABSTRACT

There is an urgent need to find cheap, safe and effective alternative analgesic agents to replace or supplement the currently available non-steroidal anti-inflammatory drugs (NSAIDs) and opioids which are associated with serious gastrointestinal and central nervous system side effects, respectively. In this work, analgesic activities of the methanol stem bark extract of Adansonia digitata were carried out in mice using acetic acid induced abdominal writhing and hot plate models for peripheral and central analgesic activities, respectively. Piroxicam (20 mg/kg, i.p) and pentazocine (20 mg/kg, i.p.) were used as standard drugs to validate the two models, respectively. In the acetic acid induced abdominal writhing test, the extract has significantly (p<0.05) and dose-dependently caused a decrease in the number of abdominal writhes in mice at all the doses tested when compared to the control group. In the hot plate test, the extract at 1000 mg/kg dose has significantly (p<0.05) increased the reaction time at 30 & 60 minutes with no significant (p<0.05) increase in reaction time at 90 and 120 minutes when compared to the control group. However, at doses of 250 & 500mg/kg dose, there was no significant (P<0.05) increase in reaction time by the extract when compared to the control group during the entire two hours duration. The result obtained concluded that the methanol stem bark extract of Adansonia digitata possesses analgesic activities which constitute the scientific basis of the traditional uses of the plant.

Keywords: Adansonia digitata, analgesics, hot plate test, acetic acid, abdominal writhes.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing