EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN VITRO QUALITY ASSESSMENT OF FIVE BRANDS OF LOW DOSE ASPIRIN TABLETS MARKETED IN ENUGU, NIGERIA

Nkemakolam Nwachukwu* and Jacinta Chizoba Okafor

ABSTRACT

This study investigated the quality of low dose aspirin (acetyl salicylic acid) tablets marketed in Enugu, Nigeria. Five brands of low dose aspirin 75 mg and 81 mg (coded LDA-A, LDA-B, LDA-C, LDA-D and LDA-E) were purchased from different retail pharmacies within Enugu. Each of the brands was evaluated for wholesomeness of both the packaging materials and tablets, organoleptic, mechanical properties, disintegration time, content of active ingredient, and dissolution profile using standard methods. The results reveal that all the containers were intact and properly labelled while the weight of the tablets ranged from 0.108 ± 1.852 - 0.273 g ± 0.703 %, crushing strength (1.58 ± 0.333 – 6.57 ± 0.453 kgF), friabilities were ≤ 1 % (except brand LDA-D), disintegration time (< 15 min), content of active ingredient (95.672 ± 0.571- 98.177 ± 0.215 %) and dissolution (> 80 %) within 30 min. All the brands met the British Pharmacopoeia specifications for uniformity of weight, content of active ingredient and dissolution. Only batches LDA-A and LDA-E passed the crushing strength test. In conclusion, all the brands of low dose aspirin contained the labelled amounts and had good dissolution but only samples LDA-A and LDA-E were of good mechanical strength. Besides the challenge of possible loss of the physical integrity of the tablets during transportation and handling, all the brands of low dose aspirin tablets were of good quality and would be therapeutically beneficial to the consumers.

Keywords: Low dose, aspirin, tablets, quality, assessment, British Pharmacopoeia.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing