EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE EFFECTIVENESS OF PROPHYLACTIC INTRAVENOUS PHENYLEPHRINE AND EPHEDRINE ON MATERNAL HEMODYNAMICS AND FETAL OUTCOME IN ELECTIVE CESAREAN SECTION UNDER SUBARACHNOID BLOCK

Dilip Kumar Bhowmick*, Pooja Bharoi, Sharmin Ara Begum, Begum Maksuda Farida Akhtar, Akhtaruzzaman AKM

ABSTRACT

Objective: In this study our goal is to evaluate the effectiveness of prophylactic intravenous phenylephrine and ephedrine on maternal hemodynamics and fetal outcome in elective cesarean section under subarachnoid block. Method: This randomized Controlled trial (RCT) study was carried out at Obstetric Operation Theatre Department of Anaesthesia, Analgesia and Intensive Care Medicine, BSMMU for a period of 12 months. A total of 90 parturients admitted for elective caesarean section at Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical Universitywere included in the study, they were divided into two groups, 45 in each. Where Group P was the phenylephrine group and Group E was the ephedrine group. Results: During the study period, the mean arterial pressure was statistically significant at 3 minutes, 6 minutes, 9 minutes, 12 minutes before the delivery of the baby and at 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, 45 minutes after the delivery. But it was found to be statistically non significant at the baseline, 15 minutes before the delivery of the baby and at 5 minutes, 10 minutes, 15 minutes, 50 minutes after the delivery of the baby.Among all the 90 parturient, 3 parturient in group P and 8 parturient in group E developed hypotension and was subsequently treated with rescue doses of vasopressor. One parturient in group P and 2 parturient in group E developed dizziness. 1 (2.2%) parturient in group P and 8 (17.8%) parturient in group E developed nausea alone and 1(2.2%) parturient in group P and 5(11.1%) in group E had nausea with vomiting which was managed by ondansetron 4 mg. 3 (6.7%) out of 45 parturient in group P developed bradycardia which was managed by atropine 0.5mg .Out of 90 parturients 2(4.4%) parturient in group p and 8(17.8%) parturient developed tachycardia. Conclusion: From our study we can conclude that, prophylactic intravenous phenylephrine bolus at the given dose remarkably reduced the incidence of subarachnoid block induced hypotension with fewer adverse maternal effects. The use of phenylephrine was associated with better foetal acid base status, and satisfactory APGAR score.

Keywords: Phenylephrine, Subarachnoid block (SAB), anaesthetic technique.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing