EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

BIOFILM FORMING PROPERTY & ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF UROPATHOGENS CAUSING CATHETER ASSOCIATED URINARY TRACT INFECTION (CAUTI)

Kyaw Zeyar Soe* and Sanjay Pratap Singh

ABSTRACT

Introduction: Catheter Associated Urinary Tract Infection (CAUTI), a common healthcare-associated infection, is difficult to manage for biofilm producing microorganisms and this property is also predisposing by nature of devise material. Moreover, multi-drugs resistance uropathogens are one of the challenging problem in healthcare facility.
Aims and Objectives: Evaluation of biofilm forming properties and antimicrobial susceptibility of uropathogenic microorganisms isolated from cases of CAUTI in Latex rubber Foley’s catheters and Silicone-coated Foley’s catheter.
Materials and Methods: Aseptically collected Urine samples of 116 individuals qualified as CAUTI were investigated to obtain uropathogenic bacteria. Their biofilm forming properties & antimicrobial resistance patterns were also evaluated. The different biofilm forming properties of uropathogens in Latex rubber Foley’s catheter and Silicone-coated rubber Foley’s catheter was also analysed.
Results: During study period, 116 patients were labelled as CAUTIs and total CAUTI rate per thousand urinary catheter days was 5.7. A total of 116 bacteria were isolated from the CAUTI patients with Escherichia coli being the most frequent isolate 35%, followed by Klebsiella pneumonia, Pseudomonas aeruginosa, Enterococcus faecalis and other Gram negative organisms. Out of 116 isolates, 56% of bacteria were found to produce biofilms. Of these, 43% were strong biofilm producers and 13% observed as moderate biofilm producers. Majority of uropathogens were found to be resistance to most of the antibiotics had been tested.
Conclusion: Enterobacteriaceae were the most common isolates and the biofilm producing isolates were observed more resistant to antimicrobials agents. Most of the Gram negative isolates were multi-drugs resistant organisms (MDRO). Using Silicone-coated Foley’s catheter can not only delay the onset of Catheter Associated Urinary Tract Infection but also have lesser proportion of biofilm producing bacteria with lower chance of multi-drugs resistant organisms (MDRO) thereby ensuring better curative treatment for the patient.

Keywords: CAUTI, Biofilm, Uroparhogens, Antimicrobial resistance.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing