EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF PARACETAMOL TABLET TO ASSESS THE BINDING PROPERTY OF SWEET LEMON PEEL PECTIN

*Maheshwari M. Bhongade, Shubham B. Kale, Avinash O. Maske and Yogeshwary M. Bhongade

ABSTRACT

The aim of present work was to extract pectin from dried as well as wet sweet lemon fruit peels to assess its binding property in tablets using paracetamol as a model drug. Firstly sweet lemon peel or its powder was subjected to simple water heating extraction method and pectin was isolated using ethanol as precipitating agent. Then after four batches were formulated using pectin in different proportions. Precompression and post compression studies were perform for each formulation. The results obtained for all precompression and post compression parameter were found within acceptable range of pharmacopoeias. On the basis of peel pectin can act as a excellent binder in dosage forms. Since it is of natural origin and sweet lemon peel available at low cost it may prove to be better binder over commercially used synthetic binders.

Keywords: Binding property, Sweet lemon peel pectin, Simple hot water based extraction.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing