EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN-VITRO ASSESSMENT OF CERIUM OXIDE NANOPARTICLES AS PROMISING DRUG-DELIVERY VEHICLES: INFLUENCE OF SURFACE FUNCTIONALIZATION

Aparna Datta*, Deblina Majumder, Preetam Guha Ray, Sayantan Dasgupta, Siddharta Mukherjee and Somenath Roy

ABSTRACT

In search of alternative materials for potential use as a drug-delivery vehicle, or as a theranostic agent, we have investigated in-vitro biocompatibility of cerium oxide (CeO2) nanoparticles, having inherent reactive oxygen species (ROS) modulating properties. Two primary concerns for injectable drug carriers, namely, hemo-compatibility and non-specific protein adsorption, have been addressed using pristine ceria, as well as CeO2 nanoparticles with activated hydroxyl, amine or thiol functional groups. In addition, cytotoxicity studies have been performed in-vitro on human hepatocellular carcinoma (HepG2) cell line. Our studies suggest that the overall biocompatibility of cerium oxide is considerably superior to silica, the widely studied metal-oxide as a potential drug career. Cytotoxicity and hemolytic activity of CeO2 can be further tuned by deploying appropriate surface functionalization strategies. Our studies revealed that grafting aminosilane moieties on the surface of nano-ceria significantly reduced hemolysis, to a value of mere 5%, for a particle concentration as high as 1000 μg/ml. Additionally, we have observed inherent cytotoxicity of CeO2 for cancer cells. Such observation paves the way to potential utilization of cerium oxide nanoparticles, not only as a drug carrier but also as a pro-oxidant therapeutic agent for cancer.

Keywords: Cerium oxide; surface functionalization; hemolysis; cytotoxicity; protein adsorption.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing