EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF AN ANTI DIABETIC DRUG

Medisetty Gayatri Devi, Lakshmi Usha Ayalasomayajula*, Radha Rani Earle and Dr. P. Uma Devi

ABSTRACT

Diabetes Mellitus is a result of reduced insulin secretion from pancreas, and insulin action in the body or both. They are several natural as well as synthetic drugs like insulin, biguanides, sulphonylureas, thiazolidinodiones, meglitinides etc. for the treatment of diabetes. Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances incretin hormone activity, sustains insulin levels, and reduces glycemia in Type II diabetes mellitus. Therefore it is an anti-diadetic drug used in the treatment of Type II diabetes mellitus and has been selected to prepare sustained release dosage forms. In present investigation an attempt has been made to design and develop Vildagliptin sustained release matrix tablets using Xanthan gum, Guar gum and their combination as release retarding polymers by direct compression method. Xanthan gum, Guar gum and their combination are used in various concentrations in the preparation of tablets. Hence sustained-release tablets were evaluated for various physical parameters namely– Hardness, Weight variation, Friability, Drug Content uniformity test etc. Drug release studies were also carried out in pH 6.8 phosphate buffer. By evaluating all the physical parameters and drug release studies F11 containing a mixture of Xanthan gum and Guar gum as release retarding polymer was optimized as the best formulation.

Keywords: Diabetes Mellitus, Sustained release matrix tablets, Direct compression method, Xanthan gum, Guar gum.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing