FORMULATION, OPTIMIZATION AND EVALUATION OF GASTRO RETENTIVE NOVEL FLOATING IN-SITU GELLING SYSTEM OF PHYLLANTHUS NIRURI

Priyanka N. Shelke, Padmanabh Deshpande*, Aniket Ithape and Mangesh Bhalekar

ABSTRACT

The oral liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach. Producing sustained release formulation of an oral liquid dosage form could be successfully augmented through a strategy of liquid in-situ gelling system. There are many advantages of in situ forming polymeric delivery systems viz. ease of administration and reduced frequency of administration, improved patient compliance and comfort. In-situ forming polymeric formulation is in sol form before administration in the body, but once administered undergoes in-situ gelation. The objective of this study was to develop a novel in-situ gel system of Phyllanthus niruri for treatment of peptic ulcer. The delivery system consists of varying concentrations of sodium alginate and calcium carbonate. The system was subjected to various in vitro study. In vitro drug release studies were conducted in 0.1 N HCl. The finalised formulation (F7) contained sodium alginate (0.5 % w/v), calcium carbonate (1.5 % w/v) which showed drug release of 90.7 %. The floating lag time was found to be less than 1 min and system was found to be floating throughout the drug release time of 12 h. The gelation occurred immediately after addition in acidic medium. The optimized cream showed maximum drug release and floating gel was found to give good results.

Keywords: Phyllanthus niruri, Corilagin, Floating in situ gel, Gastroprotective, Optimization.