EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF GASTRO RETENTIVE NOVEL FLOATING IN-SITU GELLING SYSTEM OF PHYLLANTHUS NIRURI

Priyanka N. Shelke, Padmanabh Deshpande*, Aniket Ithape and Mangesh Bhalekar

ABSTRACT

The oral liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach. Producing sustained release formulation of an oral liquid dosage form could be successfully augmented through a strategy of liquid in-situ gelling system. There are many advantages of in situ forming polymeric delivery systems viz. ease of administration and reduced frequency of administration, improved patient compliance and comfort. In-situ forming polymeric formulation is in sol form before administration in the body, but once administered undergoes in-situ gelation. The objective of this study was to develop a novel in-situ gel system of Phyllanthus niruri for treatment of peptic ulcer. The delivery system consists of varying concentrations of sodium alginate and calcium carbonate. The system was subjected to various in vitro study. In vitro drug release studies were conducted in 0.1 N HCl. The finalised formulation (F7) contained sodium alginate (0.5 % w/v), calcium carbonate (1.5 % w/v) which showed drug release of 90.7 %. The floating lag time was found to be less than 1 min and system was found to be floating throughout the drug release time of 12 h. The gelation occurred immediately after addition in acidic medium. The optimized cream showed maximum drug release and floating gel was found to give good results.

Keywords: Phyllanthus niruri, Corilagin, Floating in situ gel, Gastroprotective, Optimization.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing