EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN SILICO DOCKING OF AMINOPYRIMIDINES TARGETING RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (RAGE)

Vimalavathini R.*, Thamizharasi S., Vishvaja S., Srinithi S. and Yuvaraj G.

ABSTRACT

RAGE is a multi-ligand trans membrane receptor belonging to immunoglobulin superfamily involved in various physiological and pathological pathways of various diseases like cardio vascular diseases, cancer, neurodegenerative and auto immune diseases. Nearly 10 drugs of aminopyrimidine group (flucytosine, pyrimethamine, sulfadiazine, cytarabine, cidofovir, zalcitabine, lamivudine, capectitabine, sulfadimethoxine and sulfadimidine) were imported from PubChem database. The amino acids serine, histidine were predicted as active sites for RAGE receptor (PDB ID: 3CJJ) and the amino acids asparagine, lysine, glutamic acid, tryptophan, arginine, and tyrosine were predicted as active sites for RAGE receptor (PDB ID: 3O3U) using PDBSum database. The molecular docking were performed with RAGE receptor (PDB ID: 3CJJ and PDB ID: 3O3U) both with and without the selection of active sites, as rigid and flexible docking respectively. The docking studies were done using Autodock Tools 4.2 (Version 1.5.6rc3) software. The drugs sulfadimethoxine, sulfadimidine, capectitabine and pyrimethamine showed good docking profiles for PDB ID: 3CJJ whereas sulfadimidine, pyrimethamine, sulfadiazine and sulfadimethoxine showed good docking profiles for PDB ID: 3O3U. Finally the result from the study demonstrates the above mentioned drugs can be presumed as inhibitors of RAGE.

Keywords: RAGE, aminopyrimidine, PubChem, PDBSum, molecular docking, AutoDock.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing