EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

PHYTOCHEMICAL ANALYSIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF PERESKIA BLEO (KUNTH) DC.

Syeda Wasfiya Noor*, V. Kiran Kumar, P. Pranaya and N. Appala Raju*

ABSTRACT

Antimicrobial resistance has emerged as a cause of public health threat all over the world at a terrifying rate. The emergence of these global issues compels the continuous exploration of natural products containing antimicrobial activity. Pereskia bleo, a medicinal plant belongs to the Cactaceae family. This plant has been used traditionally for various medicinal purposes. However, previous studies regarding antimicrobial activity of Pereskia bleo leaves are still lacking. Hence, the present study was carried out to identify the phytochemical constituents and investigate the antimicrobial activity of Pereskia bleo leaves extract in different concentrations. Several phytochemical test were conducted to ascertain the presence of various phytoconstituents in the dichloromethane extract of Pereskia bleo leaves. The antimicrobial activity of four different concentrations of dichloromethane extract (50, 100, 150 and 200 mg/mL) and its ointment formulations (5, 10, 15 and 20% w/w) were evaluated by using agar well diffusion method against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The phytochemical screening depicted that the leaves extract of Pereskia bleo revealed the presence of fats and oils, phytosterols/sterols, flavonoids, terpenoids, and phenolic derivatives whereas both alkaloids and lactones were absent in it. The extract showed antimicrobial activity against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa whereas no activity was observed for Escherichia coli. However, when the dichloromethane extract incorporated into petroleum jelly, all the extract ointments revealed no inhibitory effect against the selected bacteria. In summary, it is believed that dichloromethane extract of Pereskia bleo leaves might be beneficial towards bacterial infection related disease and has much potential to be developed as a phytomedicine. The inhibitory effect of this particular plant might be attributed by the presence of flavonoids and terpenoids. However, further investigation of Pereskia bleo are required in terms of in vitro and in vivo approaches in order to ensure the effectiveness and safety of the plant.

Keywords: Pereskia bleo; phytochemical screening; antimicrobial activity; agar well diffusion method.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing