EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

MOLECULAR BASIS OF CERVICAL CANCER: A REVIEW

Shivani Singh, Dr. Sharique Ahmad* and Dr. A.N. Srivastava

ABSTRACT

Cervical cancer is sexually transmitted disease resulting from the high risk oncogene infection by Human papillomavirus of type 16 and 18. In cervical cancer cells the two viral oncogene E6 and E7 are found to be variably expressed. These genes modulate the molecule involved in innate and adaptive immunity development and also inhibit the major tumor suppressor gene p53 and pRb respectively. Molecular biology had become an encouraging structure for exploring the process of development and progression of cervical cancer. There are many fields of biomedical sciences which had investigated the oncogene and tumor suppressor gene expression from various fields one is genomics which determines the correlation between genetic expressions and pathological features by DNA Microarray technique. There are also some genetic changes which lead to cancer without any alteration in DNA sequence called Epigenetics. It comprises DNA methylation, hypermethylation and hypomethylation beside DNA there is also a major involvement of RNA in developing cancer both coding and non-coding RNA respectively. Majorly non-coding RNA is found to be upregulated in cervical cancer this whole mechanism is studied by the help of transcriptomics. Genes are translated into proteins and any alteration in genes will cause defective translation. Proteomics provides understanding of proteins in large scale and also deregulation in the proteins. Metabolomics is an analytical technique helpful for the patients of cervical cancer in predicting neoadjuvant therapy encompasses all treatments involved before primary treatment of cervical cancer. These defects in molecular mechanism ultimately cause effect in cell signaling and cell cycle. These molecular and biomedical studies could be helpful in understanding the mechanism associated with cervical cancer and also in diagnosis and prognosis of cervical cancer.

Keywords: Molecular biology, HPV, Pathogenesis, Transcriptomic, Proteomics, Metabolomics.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2020 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing