EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

LIQUISOLID COMPACTION TECHNIQUE FOR ENHANCING SOLUBILTY AND IMPROVEMENT OF DISSOLUTION

Chaursiya Ajay C.*, Patel Jignesh S., Dumpala Rajesh L.

ABSTRACT

Oral route of administration has been one of the most appropriate and broadly recognized route of delivery for most of therapeutics, because of its benefits such as easily administrable, improved patient compliance and convenience. Many drugs having poor water solubility is restricted by the dissolution rates which depends on the surface area available for dissolution. Enhancement of bioavailability of drugs having poor water solubility is the most challenging aspects for drug development. A more recent technique “Liquisolid compaction technique” has been used to formulate water insoluble medications into solid release forms. It is an innovative and capable practice to overcome this concern and it is based on mixture of insoluble drug in non-volatile solvent and combination of drug loaded solution with suitable carrier and coating substance. The usage of non-volatile solvents improves wettability and assures molecular dispersal of drug in preparation and finally points to increased solubility. Surface area of drug increased with that increased bioavailability and increased aqueous solubility of drug is observed

Keywords: Poorly water solubility, non-volatile, carrier, coating substance, liquisolid compacts.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing