EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHARMACOKINETICS AND TISSUE DISTRIBUTION STUDY OF SICKLE CELL HOME REMEDY MIXTURE

Ajayi A. O., Ademokoya A. A.*, Omotuyi I.O. and Akinyosoye F. A.

ABSTRACT

Aim: Sickle cell home remedy mixture for the relief of symptoms associated with sickle cell disease has been toxicologically investigated and ascertained in the rat model in the previous study. However, this study was designed to ascertain the level of absorption, distribution, bioavailability, metabolism and excretion of the drug which is medically refers to as pharmacokinetic (PK) to ensure its effectiveness and safety. Methods: The structural profiles, metabolites and the in vivo concentration of the mixture in blood plasma and different tissues homogenate (liver, kidney, liver, blood, heart and lung) of rats model collected at different time points after oral and intravenous (IV) administration at a single dose of 200mg/kg body weight were done using high performance liquid chromatography (HPLC) and LTQ-Orbitrap XL mass spectrometer (Thermo Electron, Begin China). Results: A 55.3% bioavailability was recorded in both the male and female rats after 30 minutes of oral administration. There was no significant difference (P<0.05) increase in the level of plasma concentration between male and female rats at the same time points of administration. Three distinct metabolites (alkoxide, acetaldehyde and sodium triglycerides) were identified in the rat’s feces and urine 24 h after administration of which the metabolic pathway were mainly hydrolysis and oxidation using cytochrome P450. Regarding the study data, One-way ANOVA was done employing Statistical Package for Social Science (SPSS) software version 21. Significant differences between male and female experimental rat groups were judged by Waller Duncan test. All data were articulated as mean ± and standard deviation (SD). Conclusion: With the results of this Pharmacokinetic study, sickle cell home remedy mixture dose intervals can be determined and adjusted more accurately for effectiveness and safety of the end users. Moreover, the clinical trial will be used to fully understand in vivo disposition of this mixture and evaluate the mechanism of its biological response.

Keywords: Pharmacokinetic, tissue distribution, sickle cell, home remedy, mixture.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2020 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing