EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

COMPARISON OF SERUM MAGNESIUM LEVEL (1-5 DAY) IN PATIENTS WITH AND WITHOUT ARRHYTHMIAS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Md. Abdul Baset, Md. Zahirul Haque, Md. Azizul Hoque, Malay Kumar Saha, Lakshman Chandra Barai, Md. Zanzibul Tareq, Abu Jafar Md. Tareq Morshed

ABSTRACT

Introduction: Magnesium deficiency leads to the progression of atheromatous plaques which ocurs as a result of hyperlipidemia. Myocardial infarction is one of the most common causes of mortality where its prognosis depends upon various factors. This study is performed to know the effect of magnesium levels in the serum of acute MI patients to the occurrence of arrhythmias. Objective: To find out the “Comparison of Serum Magnesium level (1-5 Day) in patients with and without Arrhythmias in Patients with Acute Myocardial Infarction: A Study in Rajshahi Medical College Hospital, Rajshahi, Bangladesh. Study design: Descriptive cross sectional study. Study place & period: Department of Cardiology, Rajshahi Medical College Hospital, Rajshahi from July, 2013 to November, 2013. Subjects: 50 patients with acute myocardial infarction admitted to the Department of Cardiology, Rajshahi Medical College Hospital. Methods: Data was collected from patients of any age and both sexes with acute myocardial infarction as determined by clinical features, ECG evidence and biochemical report. Blood sample for estimation of serum magnesium level was collected as early as possible within 24 hours of admission and 5th day of admission. After admission to CCU every patient was under continuous cardiac monitoring to see and record any arrhythmia within 5 days onset of symptoms. Results: A total of 50 patients of acute myocardial infarction were included during the study period. The male to female ratio in the study group was 3.17:1 and the maximum incidence of acute myocardial infarction was seen in 5th and 6th decade. In the study group mean serum magnesium level in 50 patients on day-1 is 1.86±0.39 and on Day-5 is 2.26±0.5. Mean serum magnesium level in 26 patients with arrhythmia was 1.65±0.26 on day-1 and 1.98±0.25 on day-5. In the study group, mean serum magnesium level in 24 patients without arrhythmia was 2.05±0.41 on day-1 and 2.48±0.52 on day-5. The difference between the magnesium level in patients with arrhythmia and without arrhythmia is statically significant on both day- 1 and day-5 (p<0.001). PVC was the most common type (42.5%) of arrhythmia. Conclusion: serum magnesium levels are significantly low in patients who develop arrhythmia in acute myocardial infarction.

Keywords: Coronary artery disease, acute myocardial infarction, serum magnesium level, arrhythmia.


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