EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HLA-DR TYPING AND DIFFERENT CLINICAL MANIFESTATIONS OF PAEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN A TERTIARY HOSPITAL, BANGLADESH

Susmita Das, Manik Kumar Talukder*, Md Imnul Islam, Shahana A. Rahman, Md. Mahbubul Islam, Rumana Riaaz

ABSTRACT

Introduction: Association of MHC (Major histocompatibility complex) with SLE is widely studied and it is evident that HLA class II genes are strongly associated with SLE. Among HLA-DR types, some alleles are considered as risk factors for certain clinical manifestations and some alleles may predict different organ involvement. Objective: To determine the association between HLA-DR typing with different clinical manifestations in paediatric SLE patients (pSLE). Methodology: It was a cross-sectional study. Thirty two newly diagnosed cases of pSLE were included in this study. Age and sex matched 10 apparently healthy children were selected as control. Results: Most common HLA-DR type among pSLE cases was DR15(63%) followed by DR07 (41%) and DR04 (31%). HLA-DR07 was positive in 80% of control group (p<0.05). In this study, pSLE patients presented with constitutional symptoms (93.8%) followed by skin rash (84%), renal features (75%), gastrointestinal (69%) and musculoskeletal (63%) manifestations. HLA-DR15, DR07 and DR04 were frequently positive in above mentioned manifestations, but HLA-DR13 was not present in patients with renal and haematological manifestations. HLA-DR11 and DR13 showed significant association with arthritis, and hematologic manifestation was associated with DR11.Conclusions: Among HLA-DR types, most frequently associated alleles were DR15 followed by DR07 and DR04.This study found significant association of HLA-DR typeswith different clinical manifestations in pSLE patients.

Keywords: Major histocompatibility complex, HLA-DR.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing